A tale of two neuropeptides

Circadian Clock neurons in both mammals and insects express multiple transmitters, some of which function as local signals across defined synapses while others act as diffusible signals that act over large distances. Our research is focused on studying key peptidergic clock neurons in Drosophila to understand how two neuropeptides released from the same neuron can mediate distinct behavioral and physiological functions. We focus on two neuropeptides, Pigment Dispersing Factor (PDF) and short Neuropeptide F (sNPF), both released by the small ventral lateral neurons (s-LNv), the main pacemakers in the Drosophila Circadian Clock Neuron Network. This project is a collaboration with the Shafer and Taghert Labs.